Real Madrid’s UEFA Champions League fixtures for 2010/11.
| Date | Versus | Home/Away | Score |
| 15 September | Ajax | Home | 2-0 |
| 28 September | Auxerre | Away | 0-1 |
| 19 October | AC Milan | Home | 2-0 |
| 3 November | AC Milan | Away | 2-2 |
| 23 November | Ajax | Away | 0-4 |
| 8 December | Auxerre | Home | 4-0 |
| 22 February | Lyon | Away | 1-1 |
| 16 March | Lyon | Home | 3-0 |
| 5 April | Spurs | Home | 4-0 |
| 13 April | Spurs | Away | 0-1 |
| 27 April | Barcelona | Home | 0-2 |
| 3 May | Barcelona | Away | 1-1 |